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Vaccination against cancer

How protecting ourselves from infection can also prevent cancer

In September 2008 the UK started a new vaccination programme designed to cut the risk of cervical cancer in women caused by the human papilloma virus (HPV). So how does vaccination work, and how might we improve vaccines in the future?

Our immune system is a powerful network of interacting cells and molecules with a specific function to protect us from infection. This is no small task when we consider the huge range of pathogens to which we are exposed. From viruses to bacteria, fungi and protozoa, we live in a hostile environment, so it’s not too surprising that we have evolved a complex immune system to deal with these various threats.

Immunologists like to split the immune system into two main branches. Innate immunity includes physical barriers to infection, such as skin and mucus membranes. It also includes key phagocytic cells such as neutrophils and macrophages, which circulate in the blood. Adaptive immunity requires a pool of specialised antigen-presenting cells and lymphocytes, also found in the blood. The most important antigenpresenting cells are dendritic cells, which are distributed in most tissues of your body, especially those at risk from infection. Lymphocytes are divided into different types. Some lymphocytes, called T cells, can directly kill virus-infected cells. Others, called B cells, produce antibodies that will recognise and bind to the infecting organism.

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