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Cryo-electron microscopy

Cryo-EM can reveal the 3D structures of ribosomes, proteins and viruses, almost at the resolution of individual atoms

© Veronica Falconieri/Sriram Subramaniam/National Cancer Institute/SPL

The terms in bold link to topics in the AQA, Edexcel, OCR, WJEC and CCEA A-level specifications, as well as the IB, Pre-U and SQA exam specifications.

Cryo-electron microscopy relies on quantum physics to produce images, employing electrons that can be focused using electric and magnetic fields. Diffraction limits the resolution of the images but can be reduced using electrons with a very short de Broglie wavelength.

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Physics through time

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